Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome.

doi:10.1074/jbc.274.24.17358

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Article

Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome.

The Journal of biological chemistry - 11 Jun 1999

Chen H, Wei S Q, Engelman A

Abstract excerpt

Mu-mediated polymerase chain reaction footprinting was used to investigate the protein-DNA structure of human immunodeficiency virus type I (HIV-I) preintegration complexes. Preintegration complexes were partially purified from cells after using an established coculture infection technique as well as a novel technique using cell-free supernatant from transfected cells as the source of virus. Footprinting revealed...

Topics

Cloning, Molecular
DNA Footprinting
DNA, Viral
HIV Integrase
HIV-1
Mutation
Polymerase Chain Reaction
Protein Binding
Substrate Specificity
Virus Integration

Source

Open in PubMed

Identifiers

PMID: 10358097
DOI: 10.1074/jbc.274.24.17358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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