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Article

LOH on 10p14-p15 targets the PFKFB3 gene locus in human glioblastomas.

Genes, chromosomes & cancer - 1 Dec 2011

Fleischer Michael, Kessler Renate, Klammer Angelika, Warnke Jan-Peter, Eschrich Klaus

Abstract excerpt

Loss of heterozygosity (LOH) on chromosome arm 10p is very common in high-grade gliomas and is, among others, concentrated on the region 10p14-p15. Presence of multiple tumor suppressor genes is assumed, but until now only Krüpple-like transcription factor 6 (KLF6) has been suggested as possible target of LOH in this region. On the basis of the fact that the splice variant 4 (UBI2K4) of the PFKFB3 gene, located...

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Source

Identifiers

PMID: 21987444
DOI: 10.1002/gcc.20914

Genes

PFKFB3
KLF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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