Article
Frequent LOH at chromosome 12q22-23 and Apaf-1 inactivation in glioblastoma.
Brain pathology (Zurich, Switzerland) - 1 Oct 2003
Watanabe Takuya, Hirota Yuichi, Arakawa Yasuaki, Fujisawa Hironori, Tachibana Osamu, Hasegawa Mitsuhiro, Yamashita Junkoh, Hayashi Yutaka
Abstract excerpt
Glioblastoma (GB) often has loss of heterozygosity on the chromosomes, 1p, 10p, 10q, 11p, 17p, 19q, 22q, and several others. In the case of chromosome 12q, however, it remains to be seen whether LOH occurs. Apaf-1, the apoptotic protease activating factor-1, located at chromosome 12q22-23, is a major effecter of the p53 mediated apoptosis pathway, and Apaf-1 inactivation due to chromosome 12q22-23 LOH and...
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