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Article

Decreased expression of the SIN3A gene, a candidate tumor suppressor located at the prevalent allelic loss region 15q23 in non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Jan 2008

Suzuki Hiromitsu, Ouchida Mamoru, Yamamoto Hiromasa, Yano Masaaki, Toyooka Shinichi, Aoe Motoi, Shimizu Nobuyoshi, Date Hiroshi, Shimizu Kenji

Abstract excerpt

To identify the tumor suppressor genes (TSG) associated with non-small cell lung cancers (NSCLC), we performed the loss of heterozygosity (LOH) analysis in NSCLC samples from 66 patients. We focused on the novel hot spot region on 15q14-24 with eight polymorphic microsatellite markers. Frequent allelic loss was detected in 33 of 48 informative cases (69%) at D15S984 on 15q23. We defined the fine map on the region...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17854949
DOI: 10.1016/j.lungcan.2007.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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