Article
A novel low-penetrance locus for familial glioma at 15q23-q26.3.
Cancer research - 1 Jul 2002
Paunu Niina, Lahermo Päivi, Onkamo Päivi, Ollikainen Vesa, Rantala Immo, Helén Pauli, Simola Kalle O J, Kere Juha, Haapasalo Hannu
Abstract excerpt
Epidemiological studies and case reports suggest that familial clustering of gliomas may occur in families that do not fit any known tumor syndromes. In the present study, 15 familial glioma pedigrees from a limited geographical area were hypothesized to carry the same low-penetrance susceptibility allele. We used a two-stage strategy for disease gene mapping. A genome scan in four glioma families revealed four...
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