Article
KUB3 amplification and overexpression in human gliomas.
Glia - 1 Oct 2001
Fischer U, Hemmer D, Heckel D, Michel A, Feiden W, Steudel W I, Hulsebos T, Meese E
Abstract excerpt
Gene amplification is known to occur frequently in human glioma. Recently we reported cloning of a novel gene termed glioma-amplified sequence 16 (GAS16) by microdissection-mediated cDNA capture. In this article, we demonstrate that GAS16 results from an alternative splicing process of the Ku70 binding protein 3 (KUB3) that is essential for DNA double-strand break repair. The alternative splice product was found...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.