Article
In vitro amplification and detection of variant Creutzfeldt-Jakob disease PrPSc.
The Journal of pathology - 1 Sept 2007
Jones M, Peden A H, Prowse C V, Gröner A, Manson J C, Turner M L, Ironside J W, MacGregor I R, Head M W
Abstract excerpt
Variant Creutzfeldt-Jakob disease (vCJD) poses a serious risk of secondary transmission and the need to detect infectivity in asymptomatic individuals is therefore of major importance. Following infection, it is assumed that minute amounts of disease-associated prion protein (PrP(Sc)) replicate by conversion of the host cellular prion protein (PrP(C)). Therefore, methods of rapidly reproducing this conversion...
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