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Article

Generation of a new infectious recombinant prion: a model to understand Gerstmann-Sträussler-Scheinker syndrome.

Scientific reports - 29 Aug 2017

Elezgarai Saioa R, Fernández-Borges Natalia, Eraña Hasier, Sevillano Alejandro M, Charco Jorge M, Harrathi Chafik, Saá Paula, Gil David, Kong Qingzhong, Requena Jesús R, Andréoletti Olivier, Castilla Joaquín

Abstract excerpt

Human transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative disorders that include Kuru, Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome (GSS), and fatal familial insomnia. GSS is a genetically determined TSE caused by a range of mutations within the prion protein (PrP) gene. Several animal models, based on the expression of PrPs carrying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28851967
DOI: 10.1038/s41598-017-09489-3
PMCID: PMC5575253

Genes

GSS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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