Notch1 regulates chemotaxis and proliferation by controlling the CC‐chemokine receptors 5 and 9 in T cell acute lymphoblastic leukaemia

Abstract excerpt

Tumour cells often express deregulated profiles of chemokine receptors that regulate cancer cell migration and proliferation. Notch1 pathway activation is seen in T cell acute lymphoblastic leukaemia (T-ALL) due to the high frequency of Notch1 mutations affecting approximately 60% of patients, causing ligand-independent signalling and/or prolonging Notch1 half-life. We have investigated the possible regulative...

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