Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of novel Notch target genes in T cell leukaemia

9 Jun 2009

Abstract excerpt

BACKGROUND: Dysregulated Notch signalling is believed to play an important role in the development and maintenance of T cell leukaemia. At a cellular level, Notch signalling promotes proliferation and inhibits apoptosis of T cell acute lymphoblastic leukaemia (T-ALL) cells. In this study we aimed to identify novel transcriptional targets of Notch signalling in the T-ALL cell line, Jurkat. RESULTS: RNA was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Developmental Biology and Gene Regulation
Share to T-cell and Retrovirus Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19508709
DOI: 10.1186/1476-4598-8-35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of novel Notch target genes in T cell leukaemiaPMID 19508709Read ↗

T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.Semantic proximity Read ↗

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Semantic proximity Read ↗

Novel NOTCH1-unmutated T-ALL Cell Line With Suppressed Growth by Gamma-secretase Inhibitors.Semantic proximity Read ↗

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Notch signaling in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Development of a Notch pathway assay and quantification of functional Notch pathway activity in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

NOTCH1 pathway: a molecular target in T-cell cancers?Semantic proximity Read ↗

Recent advances on NOTCH signaling in T-ALL.Semantic proximity Read ↗

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Targeting NOTCH1 in hematopoietic malignancy.Semantic proximity Read ↗

[The role and research progress of NOTCH1 in T-cell acute lymphoblastic leukemia].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.