Article
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.
Nature - 12 May 2011
Klinakis Apostolos, Lobry Camille, Abdel-Wahab Omar, Oh Philmo, Haeno Hiroshi, Buonamici Silvia, van De Walle Inge, Cathelin Severine, Trimarchi Thomas, Araldi Elisa, Liu Cynthia, Ibrahim Sherif, Beran Miroslav, Zavadil Jiri, Efstratiadis Argiris, Taghon Tom, Michor Franziska, Levine Ross L, Aifantis Iannis
Abstract excerpt
Notch signalling is a central regulator of differentiation in a variety of organisms and tissue types. Its activity is controlled by the multi-subunit γ-secretase (γSE) complex. Although Notch signalling can play both oncogenic and tumour-suppressor roles in solid tumours, in the haematopoietic system it is exclusively oncogenic, notably in T-cell acute lymphoblastic leukaemia, a disease characterized by...
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