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Tracking N- and C-termini of <i>C. elegans</i> polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles

2022-09-08

Abstract excerpt

The cilium acts as an antenna receiving and sending signals, the latter via extracellular vesicles (EVs). In C. elegans and mammals, the Autosomal Dominant Polycystic Kidney Disease (ADPKD) gene products polycystin-1 (PC1) and polycystin-2 (PC2) localize to both cilia and EVs, act in the same genetic pathway, and function in a sensory capacity, suggesting ancient conservation. However, the functions of the polycy...

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Literature Corpus work
2e4c13e4-4a87-511b-a5f4-2e0f9bc8df44
DOI
10.1101/2022.09.07.504996
Open publication

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