Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes.

Abstract excerpt

Oxidative stress is considered to promote aging and age-related disorders such as tauopathy. Although recent reports suggest that oxidative stress under certain conditions possesses anti-aging properties, no such conditions have been reported to ameliorate protein-misfolding diseases. Here, we used neuronal and murine models that overexpress human tau to demonstrate that mild oxidative stress generated by alloxan...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acetylation
• Share to Histone Deacetylases