Article

Hyperphosphorylated tau Inflicts Intracellular Stress Responses That Are Mitigated by Apomorphine

2023-05-14

Abstract excerpt

<h4>Background</h4> Abnormal phosphorylation of the microtubule-binding protein tau in the brain is a key pathological marker for Alzheimer’s disease and additional neurodegenerative tauopathies. However, how hyperphosphorylated tau causes cellular dysfunction or death that underlie neurodegeneration remains an unsolved question critical for the understanding of disease mechanism and the design of efficacious dru...

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Literature Corpus work: aa6ef8f2-5bbe-504e-be27-b292dacc5798
DOI: 10.1101/2023.05.13.540661

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