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Article

Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Nov 2008

Green Kim N, Steffan Joan S, Martinez-Coria Hilda, Sun Xuemin, Schreiber Steven S, Thompson Leslie Michels, LaFerla Frank M

Abstract excerpt

Memory loss is the signature feature of Alzheimer's disease, and therapies that prevent or delay its onset are urgently needed. Effective preventive strategies likely offer the greatest and most widespread benefits. Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance memory and synaptic plasticity. We evaluated the efficacy of nicotinamide, a competitive inhibitor of the sirtuins or...

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Identifiers

PMID: 18987186
DOI: 10.1523/JNEUROSCI.3203-08.2008
PMCID: PMC2617713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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