Article
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Experimental neurology - 1 Mar 2014
Yamada Elizabeth S, Respondek Gesine, Müssner Stefanie, de Andrade Anderson, Höllerhage Matthias, Depienne Christel, Rastetter Agnès, Tarze Agathe, Friguet Bertrand, Salama Mohamed, Champy Pierre, Oertel Wolfgang H, Höglinger Günter U
Abstract excerpt
Both genetic and environmental factors likely contribute to the neuropathology of tauopathies, but it remains unclear how specific genetic backgrounds affect the susceptibility towards environmental toxins. Mutations in the tau gene have been associated with familial tauopathies, while annonacin, a plant-derived mitochondrial inhibitor, has been implicated in an environmental form of tauopathy. We therefore...
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