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Article

Acetylation of tau inhibits its degradation and contributes to tauopathy.

Neuron - 23 Sept 2010

Min Sang-Won, Cho Seo-Hyun, Zhou Yungui, Schroeder Sebastian, Haroutunian Vahram, Seeley William W, Huang Eric J, Shen Yong, Masliah Eliezer, Mukherjee Chandrani, Meyers David, Cole Philip A, Ott Melanie, Gan Li

Abstract excerpt

Neurodegenerative tauopathies characterized by hyperphosphorylated tau include frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) and Alzheimer's disease (AD). Reducing tau levels improves cognitive function in mouse models of AD and FTDP-17, but the mechanisms regulating...

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Identifiers

PMID: 20869593
DOI: 10.1016/j.neuron.2010.08.044
PMCID: PMC3035103

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SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20869593-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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