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Article

Polygenic dissection of the bipolar phenotype.

The British journal of psychiatry : the journal of mental science - 1 Apr 2011

Hamshere M L, O'Donovan M C, Jones I R, Jones L, Kirov G, Green E K, Moskvina V, Grozeva D, Bass N, McQuillin A, Gurling H, St Clair D, Young A H, Ferrier I N, Farmer A, McGuffin P, Sklar P, Purcell S, Holmans P A, Owen M J, Craddock N

Abstract excerpt

BACKGROUND: Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder. AIMS: To test hypotheses about the relationship between schizophrenia and psychotic types of bipolar disorder. METHOD: Using a polygenic score analysis to test whether...

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Identifiers

PMID: 21972277
DOI: 10.1192/bjp.bp.110.087866
PMCID: PMC3065773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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