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Article

Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder.

Molecular psychiatry - 1 Jul 2024

Song Jie, Jonsson Lina, Lu Yi, Bergen Sarah E, Karlsson Robert, Smedler Erik, Gordon-Smith Katherine, Jones Ian, Jones Lisa, Craddock Nick, Sullivan Patrick F, Lichtenstein Paul, Di Florio Arianna, Landén Mikael

Abstract excerpt

Bipolar disorder (BD) features heterogenous clinical presentation and course of illness. It remains unclear how subphenotypes associate with genetic loadings of BD and related psychiatric disorders. We investigated associations between the subphenotypes and polygenic risk scores (PRS) for BD, schizophrenia, and major depressive disorder (MDD) in two BD cohorts from Sweden (N = 5180) and the UK (N = 2577)....

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Identifiers

PMID: 38355785
DOI: 10.1038/s41380-024-02448-1
PMCID: PMC11408248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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