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Article

Specificity of polygenic signatures across symptom dimensions in bipolar disorder: an analysis of UK Bipolar Disorder Research Network data.

The lancet. Psychiatry - 1 Aug 2023

Allardyce Judith, Cardno Alastair G, Gordon-Smith Katherine, Jones Lisa, Di Florio Arianna, Walters James T R, Holmans Peter A, Craddock Nicholas J, Jones Ian, Owen Michael J, Escott-Price Valentina, O'Donovan Michael C

Abstract excerpt

BACKGROUND: Current definitions and clinical heterogeneity in bipolar disorder are major concerns as they obstruct aetiological research and impede drug development. Therefore, stratification of bipolar disorder is a high priority. To inform stratification, our analysis aimed to examine the patterns and relationships between polygenic liability for bipolar disorder, major depressive disorder (MDD), and...

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PMID: 37437579
DOI: 10.1016/S2215-0366(23)00186-4

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