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Article

Bipolar polygenic loading and bipolar spectrum features in major depressive disorder.

Bipolar disorders - 1 Sept 2014

Wiste Anna, Robinson Elise B, Milaneschi Yuri, Meier Sandra, Ripke Stephan, Clements Caitlin C, Fitzmaurice Garrett M, Rietschel Marcella, Penninx Brenda W, Smoller Jordan W, Perlis Roy H

Abstract excerpt

OBJECTIVES: Family and genetic studies indicate overlapping liability for major depressive disorder and bipolar disorder. The purpose of the present study was to determine whether this shared genetic liability influences clinical presentation. METHODS: A polygenic risk score for bipolar disorder, derived from a large genome-wide association meta-analysis, was generated for each subject of European-American...

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Identifiers

PMID: 24725193
DOI: 10.1111/bdi.12201
PMCID: PMC4427243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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