Article

Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome

2021-05-01

Abstract excerpt

Dravet syndrome (DS) is a neurodevelopmental disorder defined by treatment-resistant epilepsy, autism spectrum disorder, and sudden death, due to pathogenic variants in SCN1A encoding the Nav1.1 sodium channel subunit. Convergent data suggest hippocampal dentate gyrus (DG) pathology. We found that optogenetic stimulation of entorhinal cortex was ictogenic in DS ( Scn1a +/- ) but not wild-type mice in vivo. Two-p...

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Literature Corpus work: 51237005-6b9f-5135-a6a6-2e4fc63cc7c1
DOI: 10.1101/2021.05.01.442271

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