Article

Targeting Amygdala-Brainstem Synapses to Reverse Prepulse Inhibition Deficits

2025-09-25

Abstract excerpt

Sensorimotor gating, a fundamental pre-attentive process, can be assessed using the acoustic prepulse inhibition (PPI) assay. PPI deficits are a hallmark endophenotype of schizophrenia and are observed across various neuropsychiatric disorders, often predicting symptoms such as attention impairments, psychosis, and other cognitive/motor dysfunctions. Reversal of PPI deficits is routinely tested in disease models a...

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Literature Corpus work: 1c5a42b9-cf98-59b4-ae24-ab70be8bffb3
DOI: 10.1101/2025.09.24.676662

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