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Article

Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region.

Journal of human genetics - 1 Jan 2020

Anyona Samuel B, Hengartner Nicolas W, Raballah Evans, Ong'echa John Michael, Lauve Nick, Cheng Qiuying, Fenimore Paul W, Ouma Collins, Lambert Christophe G, McMahon Benjamin H, Perkins Douglas J

Abstract excerpt

Cyclooxygenase-2 [(COX-2) or prostaglandin endoperoxide H2 synthase-2 (PTGS-2)] induces the production of prostaglandins as part of the host-immune response to infections. Although a number of studies have demonstrated the effects of COX-2 promoter variants on autoimmune and inflammatory diseases, their role in malaria remains undefined. As such, we investigated the relationship between four COX-2 promoter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31664161
DOI: 10.1038/s10038-019-0692-3
PMCID: PMC7255056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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