Article
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels.
BMC immunology - 25 Mar 2013
Okeyo Winnie A, Munde Elly O, Okumu Wilson, Raballah Evans, Anyona Samuel B, Vulule John M, Ong'echa John M, Perkins Douglas J, Ouma Collins
Abstract excerpt
In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe malaria resulting in high rates of pediatric morbidity and mortality in these regions. Previous studies associated interleukin (IL)-13 with pathogenesis of different infectious diseases, including...
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