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Article

Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production.

The Journal of infectious diseases - 15 Oct 2008

Ouma Collins, Davenport Gregory C, Awandare Gordon A, Keller Christopher C, Were Tom, Otieno Michael F, Vulule John M, Martinson Jeremy, Ong'echa John M, Ferrell Robert E, Perkins Douglas J

Abstract excerpt

Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1beta promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level <6.0 g/dL), and circulating IL-1beta levels were...

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Identifiers

PMID: 18781863
DOI: 10.1086/592055
PMCID: PMC2723855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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