Article
Characterization of Danio rerio Nanog and functional comparison to Xenopus Vents.
Stem cells and development - 20 May 2012
Schuff Maximilian, Siegel Doreen, Philipp Melanie, Bundschu Karin, Heymann Nicole, Donow Cornelia, Knöchel Walter
Abstract excerpt
Nanog is a homeodomain transcription factor associated with the acquisition of pluripotency. Genome analyses of lower and higher vertebrates revealed that the existence of Nanog is restricted to gnathostomata but absent from agnatha and invertebrates. To elucidate the function of Nanog in nonmammalia, we identified the Danio rerio ortholog of Nanog and characterized its role in gain and loss of function...
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