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Article

Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors.

PLoS biology - 1 Jul 2020

He Mudan, Zhang Ru, Jiao Shengbo, Zhang Fenghua, Ye Ding, Wang Houpeng, Sun Yonghua

Abstract excerpt

Maternal β-catenin activity is essential and critical for dorsal induction and its dorsal activation has been thoroughly studied. However, how the maternal β-catenin activity is suppressed in the nondorsal cells remains poorly understood. Nanog is known to play a central role for maintenance of the pluripotency and maternal -zygotic transition (MZT). Here, we reveal a novel role of Nanog as a strong repressor of...

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Identifiers

PMID: 32702011
DOI: 10.1371/journal.pbio.3000561
PMCID: PMC7402524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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