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Article

Downregulation of NANOG Induces Differentiation of Human Embryonic Stem Cells to Extraembryonic Lineages

28 Jun 2005

Abstract excerpt

The homeobox transcription factor Nanog has been proposed to play a crucial role in the maintenance of the undifferentiated state of murine embryonic stem cells. A human counterpart, NANOG, has been identified, but its function and localization have not hitherto been described. We have used a combination of RNA interference and quantitative real-time polymerase chain reaction to study NANOG in human embryonic...

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Identifiers

PMID: 15983365
DOI: 10.1634/stemcells.2005-0080

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Related research

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Downregulation of NANOG Induces Differentiation of Human Embryonic Stem Cells to Extraembryonic LineagesPMID 15983365Read ↗

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