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Article

Prognostic impact of DNMT3A mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemia.

European journal of haematology - 1 Feb 2012

Marková Jana, Michková Petra, Burčková Kateřina, Březinová Jana, Michalová Kyra, Dohnalová Alena, Maaloufová Jacqueline Soukupová, Soukup Petr, Vítek Antonín, Cetkovský Petr, Schwarz Jiří

Abstract excerpt

OBJECTIVES: Recently, mutations in DNMT3A gene have been described in about 25% acute myeloid leukemia (AML) cases, preferentially in monocytic AML. They were found to predict worse overall survival (OS) of mutated patients. PATIENTS AND METHODS: RT-PCR followed by direct sequencing was used to test the presence of DNMT3A mutations in 226 AML patients with an intermediate-risk (IR) cytogenetics. RESULTS:...

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Source

Identifiers

PMID: 21967546
DOI: 10.1111/j.1600-0609.2011.01716.x

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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