A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis.

doi:10.3899/jrheum.110685

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Article

A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis.

The Journal of rheumatology - 1 Dec 2011

Carmona F David, Serrano Aurora, Rodríguez-Rodríguez Luis, Castañeda Santos, Miranda-Filloy José A, Morado Inmaculada C, Narváez Javier, Solans Roser, Sopeña Bernardo, Marí-Alfonso Begoña, Unzurrunzaga Ainhoa, Ortego-Centeno Norberto, Blanco Ricardo, de Miguel Eugenio, Hidalgo-Conde Ana, Martín Javier, González-Gay Miguel A

Abstract excerpt

OBJECTIVE: To investigate whether a functional integrin alpha M (ITGAM) variant is involved in susceptibility to and clinical manifestations of giant cell arteritis (GCA). METHODS: A Spanish cohort of 437 white patients with biopsy-proven GCA and 1388 healthy controls were genotyped using the TaqMan allele discrimination technology. RESULTS: No association was observed between ITGAM rs1143679 and GCA (p = 0.80,...

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Identifiers

PMID: 21965647
DOI: 10.3899/jrheum.110685

Genes

GCA
ITGAM

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