Article
Role of BANK1 gene polymorphisms in biopsy-proven giant cell arteritis.
The Journal of rheumatology - 1 Jul 2010
Torres Orlando, Palomino-Morales Rogelio, Castañeda Santos, Vazquez-Rodriguez Tomas R, Morado Inmaculada C, Miranda-Filloy Jose A, Amigo-Diaz Encarnacion, Vicente Esther F, Ortego-Centeno Norberto, Fernandez-Gutierrez Benjamin, Martin Javier, Gonzalez-Gay Miguel A
Abstract excerpt
OBJECTIVE: Giant cell arteritis (GCA) is a complex polygenic disease in which more than 1 genetic locus is likely to contribute to disease susceptibility and clinical expression. BANK, an adaptor molecule, has been suggested to participate in the B cell antigen receptors-mediated calcium homeostasis. We assessed for the first time the implication of BANK1 functional variants in susceptibility to GCA. METHODS: Two...
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