Article
Cranial and extracranial giant cell arteritis do not exhibit differences in the IL6 -174 G/C gene polymorphism.
Clinical and experimental rheumatology - 1 Apr 2023
Genre Fernanda, Prieto-Peña Diana, Pulito-Cueto Verónica, Ocejo-Vinyals Javier Gonzalo, Atienza-Mateo Belén, Muñoz Jiménez Alejandro, Ortiz-Sanjuán Francisco, Romero-Yuste Susana, Moriano Clara, Galíndez-Agirregoikoa Eva, Calvo Itziar, Ortego Centeno Norberto, Álvarez-Rivas Noelia, Miranda-Filloy José A, Llorente Irene, Blanco Ricardo, Gualillo Oreste, Martín Javier, Castañeda Santos, López-Mejías Raquel, Remuzgo-Martínez Sara, González-Gay Miguel A
Abstract excerpt
OBJECTIVES: Since interleukin-6 (IL-6) is a pivotal proinflammatory cytokine implicated in the pathogenesis of giant cell arteritis (GCA), we aimed to determine the potential association of the functional IL6 -174 G/C polymorphism with GCA as well as if the single base change variation at the promoter region in the human IL-6 gene may account for differences in the clinical spectrum of GCA between cranial and...
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