Article
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function.
American journal of respiratory and critical care medicine - 1 Oct 2011
Soler Artigas María, Wain Louise V, Repapi Emmanouela, Obeidat Ma'en, Sayers Ian, Burton Paul R, Johnson Toby, Zhao Jing Hua, Albrecht Eva, Dominiczak Anna F, Kerr Shona M, Smith Blair H, Cadby Gemma, Hui Jennie, Palmer Lyle J, Hingorani Aroon D, Wannamethee S Goya, Whincup Peter H, Ebrahim Shah, Smith George Davey, Barroso Inês, Loos Ruth J F, Wareham Nicholas J, Cooper Cyrus, Dennison Elaine, Shaheen Seif O, Liu Jason Z, Marchini Jonathan, Dahgam Santosh, Naluai Asa Torinsson, Olin Anna-Carin, Karrasch Stefan, Heinrich Joachim, Schulz Holger, McKeever Tricia M, Pavord Ian D, Heliövaara Markku, Ripatti Samuli, Surakka Ida, Blakey John D, Kähönen Mika, Britton John R, Nyberg Fredrik, Holloway John W, Lawlor Debbie A, Morris Richard W, James Alan L, Jackson Cathy M, Hall Ian P, Tobin Martin D
Abstract excerpt
RATIONALE: Genomic loci are associated with FEV1 or the ratio of FEV1 to FVC in population samples, but their association with chronic obstructive pulmonary disease (COPD) has not yet been proven, nor have their combined effects on lung function and COPD been studied. OBJECTIVES: To test association with COPD of variants at five loci (TNS1, GSTCD, HTR4, AGER, and THSD4) and to evaluate joint effects on lung...
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