Article
Effects of Lung Function-Related Genes and TSLP on COPD Phenotypes.
COPD - 1 Feb 2020
Yamada Hideyasu, Hida Norihito, Masuko Hironori, Sakamoto Tohru, Hizawa Nobuyuki
Abstract excerpt
A weighted genetic risk score (GRS) based on 16 SNPs implicated in reduced lung function in both Japanese and non-Japanese populations was previously associated with the onset of COPD and asthma. We here examine the genetic impact of this lung function GRS on specific COPD phenotypes. A cohort of Japanese COPD patients (N = 270) underwent lung function testing followed by genotyping with allele-specific arrays...
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