Article
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.
PLoS genetics - 1 Mar 2009
Pillai Sreekumar G, Ge Dongliang, Zhu Guohua, Kong Xiangyang, Shianna Kevin V, Need Anna C, Feng Sheng, Hersh Craig P, Bakke Per, Gulsvik Amund, Ruppert Andreas, Lødrup Carlsen Karin C, Roses Allen, Anderson Wayne, Rennard Stephen I, Lomas David A, Silverman Edwin K, Goldstein David B
Abstract excerpt
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of alpha(1)-antitrypsin, which is present in 1-2% of individuals with COPD. We conducted a genome-wide association study (GWAS) in a homogenous case-control cohort from Bergen, Norway (823 COPD cases and 810 smoking controls) and...
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