Article
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
Nature genetics - 1 Jan 2010
Hancock Dana B, Eijgelsheim Mark, Wilk Jemma B, Gharib Sina A, Loehr Laura R, Marciante Kristin D, Franceschini Nora, van Durme Yannick M T A, Chen Ting-Hsu, Barr R Graham, Schabath Matthew B, Couper David J, Brusselle Guy G, Psaty Bruce M, van Duijn Cornelia M, Rotter Jerome I, Uitterlinden André G, Hofman Albert, Punjabi Naresh M, Rivadeneira Fernando, Morrison Alanna C, Enright Paul L, North Kari E, Heckbert Susan R, Lumley Thomas, Stricker Bruno H C, O'Connor George T, London Stephanie J
Abstract excerpt
Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV(1)) and its ratio to forced vital capacity (FEV(1)/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890...
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