Article
Genome-wide association study identifies five loci associated with lung function.
Nature genetics - 1 Jan 2010
Repapi Emmanouela, Sayers Ian, Wain Louise V, Burton Paul R, Johnson Toby, Obeidat Ma'en, Zhao Jing Hua, Ramasamy Adaikalavan, Zhai Guangju, Vitart Veronique, Huffman Jennifer E, Igl Wilmar, Albrecht Eva, Deloukas Panos, Henderson John, Granell Raquel, McArdle Wendy L, Rudnicka Alicja R, Barroso Inês, Loos Ruth J F, Wareham Nicholas J, Mustelin Linda, Rantanen Taina, Surakka Ida, Imboden Medea, Wichmann H Erich, Grkovic Ivica, Jankovic Stipan, Zgaga Lina, Hartikainen Anna-Liisa, Peltonen Leena, Gyllensten Ulf, Johansson Asa, Zaboli Ghazal, Campbell Harry, Wild Sarah H, Wilson James F, Gläser Sven, Homuth Georg, Völzke Henry, Mangino Massimo, Soranzo Nicole, Spector Tim D, Polasek Ozren, Rudan Igor, Wright Alan F, Heliövaara Markku, Ripatti Samuli, Pouta Anneli, Naluai Asa Torinsson, Olin Anna-Carin, Torén Kjell, Cooper Matthew N, James Alan L, Palmer Lyle J, Hingorani Aroon D, Wannamethee S Goya, Whincup Peter H, Smith George Davey, Ebrahim Shah, McKeever Tricia M, Pavord Ian D, MacLeod Andrew K, Morris Andrew D, Porteous David J, Cooper Cyrus, Dennison Elaine, Shaheen Seif, Karrasch Stefan, Schnabel Eva, Schulz Holger, Grallert Harald, Bouatia-Naji Nabila, Delplanque Jérôme, Froguel Philippe, Blakey John D, Britton John R, Morris Richard W, Holloway John W, Lawlor Debbie A, Hui Jennie, Nyberg Fredrik, Jarvelin Marjo-Riitta, Jackson Cathy, Kähönen Mika, Kaprio Jaakko, Probst-Hensch Nicole M, Koch Beate, Hayward Caroline, Evans David M, Elliott Paul, Strachan David P, Hall Ian P, Tobin Martin D
Abstract excerpt
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from...
Read the complete abstract on PubMed