Article
Genome-wide association study of lung function and clinical implication in heavy smokers.
BMC medical genetics - 1 Aug 2018
Li Xingnan, Ortega Victor E, Ampleford Elizabeth J, Graham Barr R, Christenson Stephanie A, Cooper Christopher B, Couper David, Dransfield Mark T, Han Mei Lan K, Hansel Nadia N, Hoffman Eric A, Kanner Richard E, Kleerup Eric C, Martinez Fernando J, Paine Robert, Woodruff Prescott G, Hawkins Gregory A, Bleecker Eugene R, Meyers Deborah A
Abstract excerpt
BACKGROUND: The aim of this study is to identify genetic loci associated with post-bronchodilator FEV1/FVC and FEV1, and develop a multi-gene predictive model for lung function in COPD. METHODS: Genome-wide association study (GWAS) of post-bronchodilator FEV1/FVC and FEV1 was performed in 1645 non-Hispanic White European descent smokers. RESULTS: A functional rare variant in SERPINA1 (rs28929474: Glu342Lys) was...
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