Article
Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls.
PloS one - 1 Jan 2017
Artigas María Soler, Wain Louise V, Shrine Nick, McKeever Tricia M, Sayers Ian, Hall Ian P, Tobin Martin D
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide; smoking is the main risk factor for COPD, but genetic factors are also relevant contributors. Genome-wide association studies (GWAS) of the lung function measures used in the diagnosis of COPD have identified a number of loci, however association signals are often broad and collectively these loci only explain a small...
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