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Article

Polymorphisms in nevus-associated genes MTAP, PLA2G6, and IRF4 and the risk of invasive cutaneous melanoma.

Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Oct 2011

Kvaskoff Marina, Whiteman David C, Zhao Zhen Z, Montgomery Grant W, Martin Nicholas G, Hayward Nicholas K, Duffy David L

Abstract excerpt

An evolving hypothesis postulates that melanomas may arise through 'nevus-associated' and 'chronic sun exposure' pathways. We explored this hypothesis by examining associations between nevus-associated loci and melanoma risk across strata of body site and histological subtype. We genotyped 1028 invasive case patients and 1469 controls for variants in methylthioadenosine phosphorylase (MTAP), phospholipase A2,...

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Identifiers

PMID: 21962134
DOI: 10.1375/twin.14.5.422
PMCID: PMC3266856

Genes

MTAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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