Article
A large-scale genome-wide association meta-analysis for nevus count provides direct insights into the genetics of melanoma.
Nature communications - 10 Mar 2026
Jayasinghe G J M Shanika R, Zhu Gu, Pandeya Nirmala, Olsen Catherine M, Martin Nicholas G, Lind Penelope A, Medland Sarah E, Gordon Scott D, Diaz-Torres Santiago, Lingham Gareth, Lee Samantha S Y, Nijsten Tamar, Kayser Manfred, Pardo Luba M, Montgomery Grant W, Hayward Nicholas K, Palmer Jane M, Hunter David J, Han Jiali, Hewitt Alex W, Falchi Mario, Bishop D Timothy, Brown Kevin M, Bataille Veronique, Mackey David A, Iles Mark M, Whiteman David C, Duffy David L, MacGregor Stuart, Law Matthew H
Abstract excerpt
A greater understanding of the biology of nevi will provide insights into the etiology of melanoma. Our large-scale meta-analysis of 14 nevus genome-wide association studies (GWAS) includes 85,965 individuals of European ancestry. We identify 29 nevus-associated loci (p < 5 × 10-8), of which 24 have not been previously reported in a GWAS conducted for nevus count alone. We further identify 255 candidate genes for...
Topics
- Humans
- Genome-Wide Association Study
- Melanoma
- Female
- Genetic Predisposition to Disease
- Male
- Nevus
- Polymorphism, Single Nucleotide