Article
Melanoma genetics: recent findings take us beyond well-traveled pathways.
The Journal of investigative dermatology - 1 Jul 2012
Law Matthew H, Macgregor Stuart, Hayward Nicholas K
Abstract excerpt
Genetic linkage and candidate gene studies have identified a number of genes involved in melanoma susceptibility, such as MC1R and CDKN2A, via the endophenotypes of pigmentation and nevus proliferation. A series of genome-wide association studies (GWASs) in 2008 and 2009 showed that a handful of additional genes (e.g., ASIP, TYR, and PLA2G6) influencing these endophenotypes also affected melanoma risk. The most...
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