IRF4 variants have age-specific effects on nevus count and predispose to melanoma.

doi:10.1016/j.ajhg.2010.05.017

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Article

IRF4 variants have age-specific effects on nevus count and predispose to melanoma.

American journal of human genetics - 9 Jul 2010

Duffy David L, Iles Mark M, Glass Dan, Zhu Gu, Barrett Jennifer H, Höiom Veronica, Zhao Zhen Z, Sturm Richard A, Soranzo Nicole, Hammond Chris, Kvaskoff Marina, Whiteman David C, Mangino Massimo, Hansson Johan, Newton-Bishop Julia A, Bataille Veronique, Hayward Nicholas K, Martin Nicholas G, Bishop D Timothy, Spector Timothy D, Montgomery Grant W

Abstract excerpt

High melanocytic nevus count is a strong predictor of melanoma risk. A GWAS of nevus count in Australian adolescent twins identified an association of nevus count with the interferon regulatory factor 4 gene (IRF4 [p = 6 x 10(-9)]). There was a strong genotype-by-age interaction, which was replicated in independent UK samples of adolescents and adults. The rs12203592(*)T allele was associated with high nevus...

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PMID: 20602913
DOI: 10.1016/j.ajhg.2010.05.017
PMCID: PMC2896771

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