Article
Genetic factors associated with naevus count and dermoscopic patterns: preliminary results from the Study of Nevi in Children (SONIC).
The British journal of dermatology - 1 Apr 2015
Orlow I, Satagopan J M, Berwick M, Enriquez H L, White K A M, Cheung K, Dusza S W, Oliveria S A, Marchetti M A, Scope A, Marghoob A A, Halpern A C
Abstract excerpt
BACKGROUND: Melanocytic naevi are an important risk factor for melanoma. Naevi with distinct dermoscopic patterns can differ in size, distribution and host pigmentation characteristics. OBJECTIVES: We examined MC1R and 85 other candidate loci in a cohort of children to test the hypothesis that the development and dermoscopic type of naevi are modulated by genetic variants. METHODS: Buccal DNAs were obtained from...
Topics
- Alleles
- Child
- Cyclin-Dependent Kinase 6
- Dermoscopy
- Female
- Genetic Loci
- Genotype
- Group VI Phospholipases A2
- Humans
- Interferon Regulatory Factors
- Male
- Nevus, Pigmented
- Poly (ADP-Ribose) Polymerase-1