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Article

Higher Nevus Count Exhibits a Distinct DNA Methylation Signature in Healthy Human Skin: Implications for Melanoma.

The Journal of investigative dermatology - 1 Apr 2017

Roos Leonie, Sandling Johanna K, Bell Christopher G, Glass Daniel, Mangino Massimo, Spector Tim D, Deloukas Panos, Bataille Veronique, Bell Jordana T

Abstract excerpt

High nevus count is the strongest risk factor for melanoma, and although gene variants have been discovered for both traits, epigenetic variation is unexplored. We investigated 322 healthy human skin DNA methylomes associated with total body nevi count, incorporating genetic and transcriptomic variation. DNA methylation changes were identified at genes involved in melanocyte biology, such as RAF1 (P = 1.2 × 10-6)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27993549
DOI: 10.1016/j.jid.2016.11.029
PMCID: PMC5754330

Genes

ARRDC1
CTC1
NID1
RAF1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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