Article
On the interplay of telomeres, nevi and the risk of melanoma.
PloS one - 1 Jan 2012
Bodelon Clara, Pfeiffer Ruth M, Bollati Valentina, Debbache Julien, Calista Donato, Ghiorzo Paola, Fargnoli Maria Concetta, Bianchi-Scarra Giovanna, Peris Ketty, Hoxha Mirjam, Hutchinson Amy, Burdette Laurie, Burke Laura, Fang Shenying, Tucker Margaret A, Goldstein Alisa M, Lee Jeffrey E, Wei Qingyi, Savage Sharon A, Yang Xiaohong R, Amos Christopher, Landi Maria Teresa
Abstract excerpt
The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres have been found to be associated with many cancers and with number of nevi, a known risk factor for melanoma. However, shorter telomeres have also been found to decrease melanoma risk. We performed a systematic analysis of telomere-related genes and tagSNPs within these genes, in relation to the risk of melanoma, dysplastic nevi,...
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