Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.

doi:10.1038/ng.410

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Article

Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.

Nature genetics - 1 Aug 2009

Falchi Mario, Bataille Veronique, Hayward Nicholas K, Duffy David L, Bishop Julia A Newton, Pastinen Tomi, Cervino Alessandra, Zhao Zhen Z, Deloukas Panos, Soranzo Nicole, Elder David E, Barrett Jennifer H, Martin Nicholas G, Bishop D Timothy, Montgomery Grant W, Spector Timothy D

Abstract excerpt

A high melanocytic nevi count is the strongest known risk factor for cutaneous melanoma. We conducted a genome-wide association study for nevus count using 297,108 SNPs in 1,524 twins, with validation in an independent cohort of 4,107 individuals. We identified strongly associated variants in MTAP, a gene adjacent to the familial melanoma susceptibility locus CDKN2A on 9p21 (rs4636294, combined P = 3.4 x...

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PMID: 19578365
DOI: 10.1038/ng.410
PMCID: PMC3080738

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MTAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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