Article
Natural variations at position 93 of the invariant Vα24-Jα18 α chain of human iNKT-cell TCRs strongly impact on CD1d binding.
European journal of immunology - 1 Jan 2012
Sanderson Joseph P, Waldburger-Hauri Kathrin, Garzón Diana, Matulis Gediminas, Mansour Salah, Pumphrey Nicholas J, Lissin Nikolai, Villiger Peter M, Jakobsen Bent, Faraldo-Gómez José D, Gadola Stephan D
Abstract excerpt
Human invariant natural killer T (NKT) cell TCRs bind to CD1d via an "invariant" Vα24-Jα18 chain (iNKTα) paired to semi-invariant Vβ11 chains (iNKTβ). Single-amino acid variations at position 93 (p93) of iNKTα, immediately upstream of the "invariant" CDR3α region, have been reported in a substantial proportion of human iNKT-cell clones (4-30%). Although p93, a serine in most human iNKT-cell TCRs, makes no contact...
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