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Article

CDR3β sequence motifs regulate autoreactivity of human invariant NKT cell receptors.

Journal of autoimmunity - 1 Apr 2016

Chamoto Kenji, Guo Tingxi, Imataki Osamu, Tanaka Makito, Nakatsugawa Munehide, Ochi Toshiki, Yamashita Yuki, Saito Akiko M, Saito Toshiki I, Butler Marcus O, Hirano Naoto

Abstract excerpt

Invariant natural killer T (iNKT) cells are a subset of T lymphocytes that recognize lipid ligands presented by monomorphic CD1d. Human iNKT T cell receptor (TCR) is largely composed of invariant Vα24 (Vα24i) TCRα chain and semi-variant Vβ11 TCRβ chain, where complementarity-determining region (CDR)3β is the sole variable region. One of the characteristic features of iNKT cells is that they retain autoreactivity...

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Antigen Presentation
Antigen-Presenting Cells
Antigens, CD1d
Autoimmunity
Complementarity Determining Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Multimerization

Receptors, Natural Killer Cell

T-Lymphocyte Subsets

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Identifiers

PMID: 26748722
DOI: 10.1016/j.jaut.2015.12.005
PMCID: PMC4792736

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